
Objective Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper limb. Various risk factors have been described for this disorder. This study aimed to investigate the relationship between CTS with body composition indexes and hand anthropometric characteristics. Design This is a case–control study. Setting The study conducted in physical medicine and rehabilitation clinic at Firoozgar Hospital, Iran University of Medical Sciences between 2019 and 2020. Participants Fifty patients with clinical symptoms of CTS and 50 controls were enrolled. Intervention The median nerve distal sensory latency (DSL) and amplitude, and distal motor latency (DML) and amplitude, were measured using a Natus Synergy Ultrapro S100 instrument. Main outcomes measure Age, hand anthropometric index, body weight, body mass index (BMI), body composition indexes and sonographically measured cross-sectional area (CSA) of median nerve were evaluated in both groups, and the relation between these variables as the incidence of CTS and its severity were investigated. Results We observed a significant correlation between CTS incidence and larger dorsovolar and mediolateral diameters of the wrist (all with P